مشخصات پژوهش

صفحه نخست /Is oxidative stress ...
عنوان
Is oxidative stress biomarkers a good indicator in paraquat poisoning?
نوع پژوهش مقاله ارائه شده (پوستر یا سخنرانی)
کلیدواژه‌ها
Paraquat , Oxidative stress, Poisoning, Liver
چکیده
Background and Aim: Paraquat (PQ), an effective and widely used herbicide, has been proven to be safe when appropriately applied to eliminate weeds. However, PQ poisoning is an extremely frustrating clinical condition with a high mortality and with a lack of effective treatments in humans. PQ is known to induce injury via reactive oxygen species (ROS) production. The purpose of this study was to investigate oxidative stress biomarkers in PQinduced liver injury. Methods: The male rats were treated by gastric gavage daily with PQ (5mg/kg/day) in combination for 7 days. After treatments, total antioxidant capacity (TAC), total thiol molecules (TTG) levele, catalase (CAT) activity,aspartatetransferase (AST) and alanintransferase (ALT) in liver hemogenate were measured Results: In this sample, the TAC and TTG were lower in the PQ group as compared with control group. However, ALT and AST levels increased in the PQ group as compared with control group. Conclusion: It is concluded that oxidative biomarkers is proper indicator of the mechanism in PQ poisoning.
پژوهشگران اکرم رنجبر (نفر اول)