مشخصات پژوهش

صفحه نخست /Comparisonofurinaryoxidativebi
عنوان
ComparisonofurinaryoxidativebiomarkersinIranian children withautism
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
ComparisonofurinaryoxidativebiomarkersinIranian children withautism
چکیده
Autismisacomplexneurodevelopmentaldisorderusuallypresentsinearlychildhoodand thoughttobeinfluencedbygeneticandenvironmentalfactors.Individualswithautism vary widelyinabilities,intelligence,andbehaviors.Itiscommonforchildrenwithautism to exhibiteatingdisordersandsomehavepreferencesforsoftandsweetenedfoodmaking them susceptibletocaries.Furthermore,awidespectrumofmedicalandbehavioral symptomsexhibitedbychildrenwithautismmakesroutinedentalcareverydifficult. Intellectualdisabilityisevidentinapproximately70%ofindividualswithautismandmost psychiatricdisorders,includingautism,areassociatedwithincreasedoxidativestress.29 subjectsdiagnosedwithautism,intheagegroupof6to12years,wereapartofthestudy. Furturemore,24normalhealthysiblingsofsameagegroupweretakenasthecontrol group. The presentstudyaimedtoevaluateoxidativestressbiomarkerssuchasurinarytotal antioxidantconcentration(TAC),catalaseactivity(CAT)andtotalthiolmolecules(TTM). The resultsshowedtheautismgrouphavesignificantlyhigherCATactivityand concomitantlowerTACandTTMconcentrationincomparisonwithcontrolgroup.The resultsarediscussedinrelationtoanincreasedvulnerabilitytooxidativedamage,which maycontributetothedevelopmentandclinicalmanifestationofsymptomsofautism
پژوهشگران اکرم رنجبر (نفر اول)، محمد رضایی(گفتار درمانی) (نفر سوم)