مشخصات پژوهش

صفحه نخست /Acellular Pertussis Vaccine: ...
عنوان
Acellular Pertussis Vaccine: Iran’s Next Step to Control the Disease?
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
Vaccines; Pertussis Vaccine; Iran
چکیده
Pertussis is a vaccine preventable disease that causes mortality and morbidity even in vaccination era. This disease causes 60 million cases and over 500000 deaths annually, which is among 10 causes of death in children worldwide (1, 2).It is the only preventable disease that still resists our attempts to be controlled (3). The most important source of disease is adults with pertussis in whom the signs and symptoms may not be considerable. Unfortunately, neither the disease nor the vaccination will cause lifelong immunity (2). Since 1948, when whole-cell bordetella pertussis vaccine introduced, we have not been desirably accomplished a success in our battle against the disease (2). Although the prevalence of pertussis has been decreased by pertussis vaccine, vaccination also changed the epidemiology of this disease; that is, the prevalence of pertussis has changed from 1- to 10-year-old children to younger infants and adults. This change in pertussis epidemiology means that more adults are being involved and as a result more young infants will be affected. Waning the effect of vaccination in adolescents and adults plays an important role in the postvaccination pattern of pertussis epidemiology (1). It has been shown that the number of subclinical adult cases transmitting the disease is also considerable (2).Hence, we would not be able to overcome the disease unless we have programs to vaccinate all age groups with several intervals and booster doses (4). Intervals are necessary because it has shown that 12 years after vaccination the protection of vaccine is unremarkable (2).
پژوهشگران ایرج صدیقی (نفر اول)، طراوت صدرالسادات (نفر دوم)