مشخصات پژوهش

صفحه نخست /A pilot double-blind ...
عنوان
A pilot double-blind placebo-controlled trial of pioglitazone as adjunctive treatment to risperidone: Effects on aberrant behavior children with autism
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
Autistic Disorder, ,Inflammation Pioglitazone, Risperidone
چکیده
Toassessthesafetyandefficacy ofpioglitazoneaddedtorisperidoneinthetreatmentofirritabilityin autistic disorder(AD),weconductedthisstudy.Ina10-week,randomized,double-blind,parallel-group, placebo-controlled clinicaltrial,44outpatientsofbothgendersaged4–12yearswithadiagnosisofAD and ascoreof Z12ontheAberrantBehaviorChecklist-Community(ABC-C)irritabilitysubscalewere included. MeanchangeofABC-Cirritabilitysubscalescoreasprimaryoutcome,changeinotherABC-C subscale scoresandpartialandcompleteresponseswerecomparedbetweentwogroups.Twentypa- tients completedthetrialineachgroup.Levelofreductionandeffectoftimetreatment interactionin the treatmentgroupweresignificant forirritability(P¼0.03), lethargy/socialwithdrawal(P¼0.04)and hyperactivity/non-compliance(P¼0.03) butnotforstereotypicbehaviorandinappropriatespeech subscales comparedwiththeplacebogroup.Vomitingandheadachewerethemostfrequentreported side-effects. Resultsofthispreliminarystudyindicatepositiveeffectsofpioglitazonecomparedwith placebo inimprovingthebehavioralsymptomsofAD.
پژوهشگران علی قلعه ایها (نفر اول)