مشخصات پژوهش

صفحه نخست /Rapid determination of ...
عنوان
Rapid determination of furosemide in drug and blood plasma of wrestlers by a carboxyl-MWCNT sensor
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
Nanosensor Furosemide Biological fluid Drug
چکیده
A novel method is developed for the quantification of furosemide in biological fluids. The method is based on the electro-reduction of Zn(II)-furosemide complex at carboxyl-MWCNT modified glassy carbon electrode. It is shown that, in Britton-Robinson buffer (pH 5.7) the reduction peak of Zn(II)-furosemide complex formed at −1.0 V (versus, Ag/AgCl). The increment of current signal obtained from the reduction peak current of the Zn(II)-furosemide complex was rectilinear with furosemide concentration in the range of 0.03 to 140.0 μg ml−1, with a detection limit of 0.007 μg ml−1. The drug recovery ranged between 97.8% and 100.8% and the mean drug recovery was 98.89%. The accuracies (relative error% and RSD%) were less than 15% and are acceptable according to the US FDA guideline for bioanalytical method validation. The sensor was used for quantification of furosemide in drug and biological fluid samples. The data of drug analysis were compared with the standard method.
پژوهشگران رشید حیدری مقدم (نفر اول)، عباس فرمانی (نفر دوم)