مشخصات پژوهش

صفحه نخست /Green tea consumption ...
عنوان
Green tea consumption improves the therapeutic efficacy of deferoxamine on iron overload in patients with β-thalassemia major: a randomized clinical study
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
Green tea, Iron, β-thalassemia major, Oxidative stress
چکیده
Green tea ( Camellia sinensis) is an important medicinal plants due to its potent antioxidant effects and metal chelating properties. This study was designed to explore the effects of green tea (GT) against iron overload in β-thalassemia major (TM) patients who were under regular chel ation therapy with deferoxamine (DFO). Based on the standard method, 14 TM patients were, randomly, selected and their blood samples were collected immediately before and one month after GT administration (12 gr/day). Then, the blood levels of iron, ferrit in, total iron -binding capacity (TIBC), lipid peroxidation (LPO), and hematological profile were determined. A significant decrease in the levels of iron (p<0.001), ferritin (p<0.01), LPO (p<0.001) and white blood cells (p<0.05) and a remarkable increase i n TIBC levels (p<0.001) were noticed in the blood samples of TM patients thirty days after GT therapy while no significant changes were observed in the other hematological parameters. GT could be used as a supplement to DFO therapy in TM patients.
پژوهشگران امیر نیلی احمد آبادی (نفر چهارم)