مشخصات پژوهش

صفحه نخست /Sildenafil, a Selective ...
عنوان
Sildenafil, a Selective Inhibitor of type 5 phosphodiesterase, attenuates Bleomycin-induced Lung Fibrosis in Rat
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
Pulmonary fibrosis, phosphodiesterase inhibitors, oxidative stress, bleomycin, sildenafil
چکیده
ABSTRACT Sildenafil is a selective inhibitor of type 5 phosphodiesterase that has antioxidant and anti-inflammatory effects. The present study aimed to investigate protective effects of sildenafil on bleomycin (BLM)-induced lung fibrosis in rat. Animals were divided into five groups and treated according to the following treatments: group 1 received daily normal saline solution, intraperitoneally (ip); group 2 received a single dose of BLM (7.5 IU/kg), intratracheally, and then received normal saline solution like the control group; groups 3, 4 and 5 were BLM groups which received sildenafil (5, 10 and 25 mg/kg/day ip, respectively) from 1 week before to 3 weeks after BLM administration. After 28 days, the animals were killed and then the changes of hydroxyproline (HP) and histology were evaluated in lung tissue. Findings of this study showed that HP level was significantly lower in the sildenafil treated rats as compared to BLM group. In addition, the HP changes were well related with the pathological findings. This study suggests that blocking of type 5 phosphodiesterase may prevent progression of BLM-induced lung fibrosis.
پژوهشگران امیر نیلی احمد آبادی (نفر ششم به بعد)