مشخصات پژوهش

صفحه نخست /Sildenafil, a Selective ...
عنوان
Sildenafil, a Selective Inhibitor of type 5 phosphodiesterase, attenuates Bleomycin-induced Lung Fibrosis in Rat
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
Pulmonary fibrosis, phosphodiesterase inhibitors, oxidative stress, bleomycin, sildenafil
چکیده
The present study aimed to investigate effects of sildenafil on bleomycin (BLM) -induced lung fibrosis in rat. Animals were divided into five groups and treated according to the following treatments: group 1 received daily normal saline, intraperitoneally (ip); group 2 received a single dose of BLM (7.5 IU/kg), intratracheally, and then received normal saline like the control group; groups 3, 4 and 5 were BLM groups which received sildenafil (5, 10 and 25 mg/kg/day ip, respectively) from 1 week before to 3 weeks after BLM administration. Finally, the animals were killed and the changes of hydroxyproline (HP) and his tology were evaluated in lung tissue. The results showed that HP level was significantly lower in the sildenafil treated rats as compared to BLM group. In addition, the HP changes were well related with the pathological findings. This study suggests that b locking of type 5 phosphodiesterase may prevent progression of BLM -induced lung fibrosis.
پژوهشگران امیر لرکی هرچگانی (نفر ششم به بعد)