مشخصات پژوهش

صفحه نخست /The relationship between some ...
عنوان
The relationship between some endometrial secretion cytokines and in vitro fertilization
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
Cytokine, In vitro fertilization, Outcome, Endometrium, Implantation.
چکیده
Background: Endometrial secretion analysis is a non-invasive and promising method in evaluation of endometrial receptivity Objective: The aim of the present study was to assess the relationship between the success rate of IVF procedures and some endometrial secretion cytokines, including interleukin-1β (IL-1β), tumor necrosis factor (TNF-α), interferon gamma-induced protein 10 (IP-10), and monocyte chemoattractant protein (MCP) Materials and Methods: In a prospective cohort study, 50 women selected for IVF met the study inclusion criteria. All the patients underwent endometrial secretion aspiration prior to embryo transfer. The level of IL-1β, TNF-α, IP-10 and MCP were analyzed by enzyme-linked immunosorbent assay method using special standard kits. To detect successful implantation and pregnancy patients underwent serum human chorionic gonadotropin measurements and ultrasound evaluation Results: Five samples were excluded. Nine women (20%) had successful clinical pregnancies, which resulted in live birth. Other 36 women (80%) were classified as failed pregnancy. Comparison of cytokine levels showed lower concentrations of TNF-α, IP-10, and MCP in the group with successful clinical pregnancy compared to the group with failed pregnancy (p=0.007, 0.005 and 0.001, respectivelyHowever, no significant difference was revealed in IL-1β levels between two groupsp=0.614 Conclusion: The current study suggested that lower concentrations of TNF-α, IP-10, and MCP in endometrial secretions might be associated with improved endometrial receptivity and IVF outcome. Regarding IL-1β, no statistically significant differences were seen between the groups with and without successful pregnancy.
پژوهشگران محمد احسان رحیمی نژاد (نفر اول)، امیرحسین مودب (نفر دوم)، مهرنوش ابراهیمی (نفر سوم)، صغری ربیعی (نفر چهارم)، علیرضا زمانی (نفر پنجم)