مشخصات پژوهش

صفحه نخست /بررسی مقایسه ای اثربخشی و ...
عنوان بررسی مقایسه ای اثربخشی و عوارض داروهای مخدر فنتانیل، سوفنتانیل و آلفنتانیل در بیماران تحت سنگ شکنی با امواج شوکی خارج اندامی
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها Key words: Alfentanil, Analgesia, Fentanyl, Lithoripsy, Sufentanil
چکیده Background: Despite of ESWL that is non invasive method for treatment of renal stone, energy that is I eleased in enter area causes pain which is out of tolerance threshold and needs analgesic drugs. We decided to compare efficacy and adverse effects of three new generation of opioids including Fentanyl, Sufentanil and Alfentanil in patients undergoing ESWL. Material & Methods: This study was a double blind clinical trial and was done on 90 patients under ESWL, were accidentally divided in three equal groups to evaluate efficacy and adverse effects of three drugs. In first group Fentanyl 1 µ g/kg, in second group Sufentanil 0.15 µg/kg and in third group Alfentanil 5 µ g/kg was given IV, 3 minutes before beginning of ESWL. Additive doses were given on the requisition of patients. We analyzed our data by SPSS 9.01 software and statistical tests. Results: Analyzing data shows no difference among 3 goups in demographic characteristics. In review point of efficacy, the use of intermittent doses of Fentanyl was dramatically less than Alfentanil (2.6 v.s 3.3) (p=0.047). Average doses of Sufentanil was less than Alfentanil (6.5 v.s 8.3) (p=0.049). Visual analogue scale (VAS) in fentanyl and sufentanil groups was lesser than Alfentanil group (3.4 v.s 4. 7) {p=0.03). Adverse effects including changes in systolic and diastolic blood pressure and heart rate and SP02, incidence of nausea, vomiting and shivering had no significant difference between the groups. Conclusion: Based on the results of this study we recommend using Fentanyl and Sufentanil in patients undergoing ESWL
پژوهشگران هوشنگ باب الحوائجی (نفر اول)، افشین فرهانچی (نفر دوم)، مریم داودی (نفر سوم)