مشخصات پژوهش

صفحه نخست /HLA genes as modifiers of ...
عنوان
HLA genes as modifiers of response to IFN-β-1a therapy in relapsing-remitting multiple sclerosis
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
HLA • IFN-β• multiple sclerosis
چکیده
This study investigated the influence of HLA class-I and -II genes in the response to IFN-βin relapsing-remitting multiple sclerosis (MS) patients. Patients & methods: In this cohort, 231 relapsing-remitting MS patients who are classified into IFN-β responders (n = 146) and nonresponders (n = 85) and 180 ethnic-matched healthy controls were analyzed. Clinical outcome of IFN-βtherapy particularly Expanded Disability Status Scale scores were evaluated in relation to HLA-A, -B and -DRB1 alleles and haplotypes. Results:Increased frequencies of HL A- DRB1*04allele and HLA-A*03-B*44- DRB1*04haplotype, and decreased frequency of HLA- B*15were associated with better response to IFN-βtreatment. Conclusion:The possibility of genetic screening particularly HLA typing prior to starting IFN-βtherapy for MS may permit the identification of likely responders or nonresponders.
پژوهشگران قاسم سلگی (نفر ششم به بعد)