مشخصات پژوهش

صفحه نخست /Effect of Topical Sucralfate ...
عنوان
Effect of Topical Sucralfate vs Clindamycin on Posttonsillectomy Pain in Children Aged 6 to 12 Years A Triple-Blind Randomized Clinical Trial
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
Topical Sucralfate - Clindamycin Posttonsillectomy Painl
چکیده
IMPORTANCE Postoperative sore throat is one of the most common problems after tonsillectomy. Antibiotics remove the local flora and reduce inflammation and thus may reduce postoperative pain after tonsillectomy. OBJECTIVE To assess the effect of topical sucralfate and clindamycin on local pain reduction after tonsillectomy in children aged 6 to 12 years. DESIGN, SETTING, AND PARTICIPANTS Triple-blind randomized clinical trial of children aged 6 to 12 years with sleep apnea or snoring due to adenotonsillar hypertrophy and chronic airway obstruction or with chronic infections who were candidates for tonsillectomy at Besat Hospital, Hamadan University of Medical Sciences, from May to October 2013. INTERVENTIONS Patients were randomly assigned to receive sucralfate mouthwash, clindamycin mouthwash, or placebo (cellulose). The oral cavity was washed before and immediately after surgery with 10 mL of the prepared solution for 1 minute and then suctioned. Then, 8 hours after surgery, the patients were asked to keep 10 mL of the prepared mouthwash solution in their mouths for 1 minute 3 times a day for 3 days. MAIN OUTCOMES AND MEASURES Postoperative sore throat evaluated daily for 5 days using the Faces Pain Scale–Revised. RESULTS Of 110 patients enrolled, 101 patients remained for analysis. Patients in the placebo group had significantly higher mean (SD) throat pain scores than did patients in both drug groups on postsurgery days 1 through 4. Day 1 scores were 8.00 (1.84) for placebo and 6.00 (1.84) for sucralfate and 6.79 (1.87) for clindamycin (P = .001). Pain scores were not significantly different on day 5. Acetaminophen use was more common in the placebo group on days 3 and 4 (2.97 and 2.44) vs the sucralfate group (2.24 and 2.15) and the clindamycin group (2.36 and 2.12) (P = .001 and .02, respectively). Bleeding on day 1 was more common in the placebo group (3 of 34) vs none in the drug groups. Food intolerance on day 1 was less common in patients receiving sucralf
پژوهشگران جوانه جهانشاهی (نفر اول)، سارا پذیرا (نفر دوم)، فرهاد فراهانی (نفر سوم)، فرناز هاشمیان (نفر چهارم)، نرگس شکری ( تسویه حساب) (نفر پنجم)، بهروز کارخانه ای (نفر ششم به بعد)، جلال پورالعجل (نفر ششم به بعد)