مشخصات پژوهش

Carboplatin is a chemotherapeutic agent used against various malignancies such as ovarian carcinoma. The aim of study is to evaluate the efficiency of pegylated liposomal nanoparticles as carboplatin carrier. Nanoparticles were synthesized using thin film hydration technique and characterized for shape morphology, particle size, zeta potential and drug-release properties. In the next step, A2780S and A2780CP ovarian cancer cell lines were used to determine the efficacy of nanodrug by MTT assay. The particle size and zeta potential of nanodrug were measured 244.3±19.6 nm and 22.9±1.7 mV, respectively. High encapsulation capacity (78.6±3.7%) confirmed the efficiency of technique. The cytotoxicity results also showed that nanodrug compared to free drug improve the efficacy of carboplatin against both A2780S (P<0.01) and A2780CP (P<0.05) cell lines. In conclusion, the findings of our study suggested pegylated liposomal nanocarriers are proper for carboplatin delivery to ovarian cancer cell lines A2780S and A2780CP. Indian Journal of Clinical Biochemistry