مشخصات پژوهش

صفحه نخست /A new approach using ...
عنوان
A new approach using autologous platelet-rich plasma to treat infertility and to improve population replacement rate
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
Autologous Platelet-Rich Plasma ,ecurrent implantation failure
چکیده
Dear Editor-in-Chief The total fertility rate (TFR) or the number births over a woman's lifetime, has reached 1.8 in 2012 which is the lowest among Islamic countries, and even below the world average of 2.1 births per woman 1-2 . This is less than population replacement rate. Furthermore, increasing age of marriage and change in lifestyle such as exposure to environment toxins increased the incidence rate of infertility 3 . More than three million people and nearly 15% of couples suffer from infertility 4 . This dilemma results in adverse economic consequences and physical, mental, and emotional problems to families. Despite progress made in the field of assisted reproductive technology (ART), multiple embryo failed to implant. A significant percentage of In Vitro Fertilization (IVF) failure is due to the endometrial receptivity 5 . Implantation requires to good quality embryo to provide a good coordination between mother and fetus. Human endometrium undergoes significant changes during implantation and immune cells and their secreted substances such as granulocyte colony-stimulating factor (G-CSF) in the luteal phase play an important role 6 . In an effort to increase the thickness of endometrium, several approaches have been made, but the results are still questionable. Platelets contain a significant amount of growth factors 7 that have positive effects on local tissue repair 8 . Larson et al., successfully developed bovine embryos during the fourth cell cycleusing platelet-derived growth factor (PDGF) 9 . This was the beginning of an evolution in reducing abortion rate by increasing endometrial thickness. Thereafter, further animal and human studies were conducted to demonstrate the efficacy of PDGF administration for infertility. Chang et al. administered intrauterine infusion of platelet rich plasma (PRP) in infertile women with thin endometrium and reported good results 4 pregnancy from five patients with thin endometrium and poor response to conventional the
پژوهشگران مرضیه سنوئی فریمانی (نفر اول)، مریم بهمن زاده (نفر دوم)، جلال پورالعجل (نفر سوم)