مشخصات پژوهش

صفحه نخست /FOXP3gene variations and ...
عنوان
FOXP3gene variations and susceptibility to autism: A case–control study
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
Autism Spectrum Disorders / Forkhead Box P3 gene/ Polymorphism
چکیده
Autism Spectrum Disorders (ASD) are a group of heterogeneous neurodevelopmental disorders associated with immune system dysregulation. There are supporting evidences for the role ofForkhead Box P3(FOXP3)geneasa lineage specification factor of regulatory T cells in the pathogenesis of ASD. The aim of this study was to explore possible relationship between genetic variants rs2232365 and rs3761548 ofFOXP3and ASD in 523 ASD patients versus472 control individuals. Allele frequency analyses showed significant overpresentation of rs2232365-G allele in casesversuscontrols. In addition, rs2232365 GG genotype was associated with ASD in dominant inheritance model. Haplotype analysis revealed no significant association of any estimated block of rs2232365/ rs3761548 with ASD. Our study indicated that rs2232365 is associated with ASD
پژوهشگران محمدرضا صفری (نفر اول)، علیرضا کمکی (نفر پنجم)، محمد مهدی افتخاریان (نفر ششم به بعد)