مشخصات پژوهش

صفحه نخست /Effect of consanguinity on ...
عنوان
Effect of consanguinity on low birth weight: a meta-analysis
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
Consanguinity; Low Birth Weight; Meta-Analysis
چکیده
Background: Consanguinity (when couples share at least one common ancestor) is a public health issue with a variety of distributions and incidence rates worldwide. Several epidemiological studies have explored the association between consanguinity and low birth weight (LBW). However, the results are inconsistent. This meta-analysis aimed to explore the overall association between consanguineous marriage and LBW. Methods: We searched PubMed, Web of Science, Scopus, ScienceDirect, and reference lists of articles to May 2015. We enrolled cohort, case-control, and cross-sectional studies addressing the association between consanguinity and LBW. We assessed heterogeneity using Q-test and I2 statistic. We explored publication bias using the Egger's and Begg's tests and the funnel plot. We meta-analyzed the data and reported the overall odds ratio (OR) and mean difference with 95% confidence intervals (CI) using the random-effects model. Results: We included 24 out of 3941 retrieved studies, with 44,131 participants. We indicated that LBW was significantly associated with first-cousin marriages (OR=1.36; 95% CI: 1.03, 1.69) and non-significantly with second-cousin marriages (OR=1.20; 95% CI: 0.49, 1.91). Furthermore, the first-cousin marriages can reduce the birth weight of siblings of consanguineous couples 144 gr more than that of non-consanguineous ones. Conclusions: This meta-analysis measured the association between consanguinity and LBW. Based on the current evidence, consanguineous marriage can increase the risk for LBW. However, further evidence based on large cohort studies being conducted in different settings is required to make a robust conclusion regarding the effect of consanguinity on LBW.
پژوهشگران جلال پورالعجل (نفر اول)