مشخصات پژوهش

صفحه نخست /Hepatoprotective effects of ...
عنوان
Hepatoprotective effects of Vaccinium arctostaphylos against CCl4-induced acute liver injury in rats
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
antioxidants; carbon tetrachloride (CCl4); hepatotoxicity; Vaccinium arctostaphylos.
چکیده
Background: This study was carried out to evaluate the antioxidant and hepatoprotective effects of Vaccinium arctostaphylos (V.a) methanolic extract on carbon tetrachloride (CCl4)-induced acute liver injury in Wistar rats. Methods: Total phenolic and total flavonoid contents as well as antioxidant activity of V.a were determined. Extracts of V.a at doses of 200 and 400 mg/kg were administered by oral gavage to rats once per day for 7 days and then were given an intraperitoneal injection of 1 mL/kg CCl 4 (1:1 in olive oil) for 3 consecutive days. Serum biochemical markers of liver injury, oxidative markers, as well as hydroxyproline (HP) content and histopathology of liver were evaluated. Results: The obtained results showed that V.a had strong antioxidant activity. Treatment of rats with V.a blocked the CCl 4-induced elevation of serum markers of liver function and enhanced albumin and total protein levels. The level of hepatic HP content was also reduced by the administration of V.a treatment. Histological examination of the liver section revealed that V.a prevented the occurrence of pathological changes in CCl4-treated rats.
پژوهشگران علیرضا پوینده روان (نفر اول)، مهدی بهمنی (نفر دوم)، حمیدرضا قاسمی بصیر (نفر سوم)، ایرج صالحی (نفر چهارم)، ابراهیم عباسی عشاقی (نفر پنجم)