مشخصات پژوهش

صفحه نخست /Validating the IBIS and ...
عنوان
Validating the IBIS and BOADICEA Models fo Predicting Breast Cancer Risk in the Iranian Population
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
Breast neoplasms, Case-control studies, Risk assessment, Software validation, Statistical models
چکیده
The validity of the IBIS model was evaluated for predicting breast cancer risk in the Iranian population. We performed a case-control study, enrolling 1633 Iranian women. We indicated that the discrimination of cases and noncases based on the IBIS model was better than the BOADICEA model for the Iranian population, although the discrimination of both models was relatively low. Background: Several approaches have been suggested for incorporating risk factors to predict the future risk of breast cancer. The Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) and International Breast Cancer Intervention Study (IBIS) are among these approaches. We compared the performance of these models in discriminating between cases and noncases in the Iranian population. Patients and Methods: We performed a case-control study in Tehran, from November 2015 to April 2016, and enrolled 1633 women aged 24 to 75 years, including 506 cases of breast cancer, 916 population-based controls, and 211 clinicbased controls. We calculated and compared the risk of breast cancer predicted by the IBIS and BOADICEA models and the logistic regression model. For model discrimination, we computed the area under the receiver operating characteristic (ROC) curve. Results: The risk of breast cancer predicted by the IBIS model was higher than the BOADICEA model, but lower than the logistic model. The area under the ROC plots indicated that the logistic regression model showed better discrimination between cases and noncases (71.53%) compared with the IBIS model (49.36%) and BOADICEA model (35.84%). Based on the Pierson correlation coefficient, the correlation between IBIS and BOADICEA models was much stronger than the correlation between IBIS and logistic models (0.3884 and 0.1639, respectively). Conclusion: The IBIS model discriminated cases and noncases better than the BOADICEA model in the Iranian population. However, the discrimination of the logistic regression
پژوهشگران جلال پورالعجل (نفر چهارم)