مشخصات پژوهش

صفحه نخست /Determination of cytokine ...
عنوان
Determination of cytokine levels in multiple sclerosis patients and their relevance with patients' response to Cinnovex
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
Cytokine IFN-β Multiple sclerosis
چکیده
Multiple sclerosis (MS) is a heterogeneous chronic immune-mediated disorder of the central nervous system (CNS) with several environmental and genetic factors participating in its development and disease course. Interferon (IFN)-βtherapy is considered as the first line treatment in this disorder. The present study enrolled 231 relapsing-remitting MS patients who were diagnosed as IFN-βresponders (n = 146) and non-responders (n = 85). Serum cytokine levels were analyzed by commercially available ELISA kits in distinct groups based on HLA-A, -B and -DRB1 alleles. IFN-γlevels were significantly higher in responders compared with non-responders, whereas IL-17A and IL-6 had the opposite trend. The levels of IL-10 and IL-4 were not significantly different between two groups. IFN-γand IL-17A levels were associated with response to IFN-β. Comparison of cytokine levels revealed higher IFN-γlevels in HLA-DRB1∗04positive patients (n = 72) compared withHLA-DRB1∗04 negative patients (n = 159). In responder group, patients who were positive forHLA-DRB1∗15had significantly higher levels of IL-6 compared toHLA-DRB1∗15negative patients. IL-17A levels tend to be higher in responder patients who were positive forHLA-DRB1∗04compared with those were negative for the same allele. This study suggests that the serum levels of pro- and anti-inflammatory cytokines are different among IFN-βresponders and non-responders. Future studies are needed to confirm their efficiency in determination of response to IFN-βin MS patient
پژوهشگران قاسم سلگی (نفر سوم)