مشخصات پژوهش

صفحه نخست /Salivary total antioxidant ...
عنوان
Salivary total antioxidant power (TAP) biomarker in patients with idiopathic tinnitus
نوع پژوهش مقاله ارائه شده (پوستر یا سخنرانی)
کلیدواژه‌ها
Tinnitus, Oxidative stress, Antioxidant power, Saliva
چکیده
Introduction: Tinnitus is one of the most prevalent disabilities in developed countries; nonetheless understanding the mechanisms of its generation still remains a challenge for physiologists, otolaryngologists and audiologists. The aim of this study was to evaluate total antioxidant power (TAP) in patients with tinnitus in comparison with the control group. Materials and Methods: This cross-sectional study was conducted on a series of 20 patients presenting idiopathic tinnitus, and 20 normal subjects who were matched based on age, sex and pure tone audiometric threshold. After audiometric tinnitus matching tests saliva samples were taken from each of the subjects. TAP was measured in saliva samples with Ferric Reducing Ability of Plasma (FRAP) method which evaluates ability of ferric ion reduction. The data were analyzed by SPSS Version 20 with Student T-test. Results: TAP level was 1.77±0.76 Umol/ml and 5.47±0.79 Umol/ml in tinnitus patients and control groups respectively. The difference was statistically significant (P value=0.01). Conclusion: These results showed that oxidative stress in patients with idiopathic tinnitus may be consequence of an imbalance in oxidant/antioxidant homeostasis. Therefore, it may be useful to recommend antioxidant medications or diet for these patients.
پژوهشگران زهرا فراهانی( عضو مرکز) (نفر اول)، سیده ساره جوادی (نفر دوم)، اکرم رنجبر (نفر سوم)، مریم عمادی (نفر چهارم)، فرهاد فراهانی (نفر پنجم)