مشخصات پژوهش

صفحه نخست /Buprenorphine augmentation ...
عنوان
Buprenorphine augmentation improved symptoms of OCD, compared to placebo - Results from a randomized, double-blind and placebocontrolled clinical trial
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
Buprenorphine augmentation improved symptoms of OCD, compared to placebo - Results from a randomized, double-blind and placebocontrolled clinical trial
چکیده
Background: In the search for new psychopharmacologic options in the treatment of obsessive compulsive disorders (OCD), some findings suggested that augmentation with buprenorphine, a partial-opioid agonist used to treat opioid addiction, moderate acute pain and moderate chronic pain, is worthy of consideration. Accordingly, to explore this possibility further, a double-blinded, placebo controlled clinical trial was performed. Method: A total of 43 patients (mean age: 34.41 years; SD = 6.58; 53.5% males) with refractory OCD and treated with SSRIs or clomipramine at therapeutic dosages were randomly assigned either to an adjuvant buprenorphine or to an adjuvant placebo condition. Patients completed the Yale-Brown-Obsessive Compulsive Scale (Y-BOCS) at baseline, weeks 3, 9 and 12 (study completion). Buprenorphine (2 -4 mg; sublingual) and placebo (tablets with identical shape, color, consistency, and scent) were given daily. Results: Symptoms of obsessive-compulsive disorders decreased over time, but more so in the buprenorphine than in the placebo condition. Substantial improvements were observed up to week 3 and then 9. Response and partial response were observed in the buprenorphine at week 9 more than in the placebo condition. The advantage had disappeared by week 12. Conclusions: The pattern of results suggests that adjuvant buprenorphine augmentation can reduce symptoms of obsessive-compulsive disorders after only three weeks, compared to a placebo. Adjuvant buprenorphine seems to accelerate symptom improvement. (C) 2017 Elsevier Ltd. All rights reserved.
پژوهشگران محمد احمدپناه (نفر اول)، امین ریحانی (نفر دوم)، علی قلعه ایها (نفر سوم)، علیرضا سلطانیان (نفر چهارم)، محمد حقیقی (نفر پنجم)، لیلا جهانگرد (نفر ششم به بعد)