مشخصات پژوهش

صفحه نخست /Association between serum ...
عنوان
Association between serum concentration of 25-hydroxyvitamin D and community-acquired pneumonia: a case-control study
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
vitamin D de ciency, community-acquired infections, pneumonia
چکیده
Background: Community-acquired pneumonia (CAP) is a common disease with signi cant morbidity and mortality. There is evidence that vitamin D de ciency can be associated with infectious diseases. The aim of this study was to compare the levels of vitamin D between patients with CAP and healthy controls. Methods: In a case-control study on 73 patients with CAP and 76 healthy controls, the serum concentration of 25-hydroxyvitamin D (25[OH]D) was measured. Severity and outcomes of disease and also duration of hospital stay were compared in patients with different levels of 25(OH)D. The severity of CAP was assessed using the CURB-65 score (confusion, uremia, respiratory rate, low blood pressure, age ≥65 years) and was also re ected by the length of hospital stay, admission to intensive care unit (ICU), and 30-day mortality. Results: In total, 81.2% of the study population had vitamin D levels <30 ng/dL. The risk of pneumonia among subjects with de cient vitamin D levels was 3.69 (95% CI: 1.46, 9.31) times of those with suf cient vitamin D level (P=0.006). Prevalence of severe de ciency of vitamin D in scores three and four of CURB-65 (59.38%), was far more than scores one and two (31.71%). Also, results indicated patients with severe de ciency had a higher risk for ICU admission, 30-day mortality, and longer hospitalization stay, but these were not statistically signi cant. Conclusion: According to ndings, a low level of 25(OH)D is associated with a higher inci- dence of CAP and more severe disease. It is recommended to pay more attention to vitamin D de ciency in infectious diseases, particularly in CAP patients.
پژوهشگران مژگان ممانی (نفر اول)، ندا موصلی (نفر دوم)، حمیدرضا قاسمی بصیر (نفر سوم)، دکتر مریم واشقانی ( تسویه حساب) (نفر چهارم)، جلال پورالعجل (نفر پنجم)