کلیدواژهها
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Recurrent implantation failure, Platelet-rich plasma, Embryo transfer, Assisted
reproductive technology, Pregnancy outcome, Embryo implantation
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چکیده
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Background: Platelets contain a significant amount of growth factors that have
positive effects on local tissue repair and endometrial receptivity.
Case: Here we present a 45-yr-old woman with primary infertility and two failed in
vitro fertilization (IVF) cycles who was candidate to receive donor eggs. Five
consecutive frozen-thawed embryo transfer cycles with good quality embryos were
performed within 2 yr. With the diagnosis of recurrent implantation failure (RIF),
the patient was treated for improving endometrial receptivity with intrauterine
administration of autologous platelet-rich plasma (PRP), 24 hr before embryo
transfer. The patient gave birth to a healthy baby boy weighing 2350 gr in the
cesarean section.
Conclusion: Extensive literature search suggests that this is the first successful
pregnancy after administration of PRP in a woman with RIF. Local administration
of PRP before embryo transfer may play a vital role in successful implantation .
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