مشخصات پژوهش

صفحه نخست /Association of serum ...
عنوان
Association of serum procalcitonin and C-reactive protein levels with CURB-65 criteria among patients with community-acquired pneumonia
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
procalcitonin, community-acquired pneumonia, C-reactive protein, CURB-65
چکیده
Background: The concentration of diagnostic markers such as inflammatory biomarkers including procalcitonin (PCT) and C-reactive protein (CRP) increases in bacterial infections. The aim of this study was to compare serum PCT and CRP levels with CURB-65 ranking, in the patients with community-acquired pneumonia (CAP). Patients and methods: In a cross-sectional study, 93 hospitalized patients with a definite diagnosis of CAP, considering inclusion and exclusion criteria, were enrolled. Serum PCT and CRP levels and their relations with CURB-65 criteria were assessed. Results: The mean serum levels of PCT and CRP were 3.64±12.32 ng/mL and 75.01±51.93 mg/L, respectively. There was a statistically significant association between CURB-65 criteria and serum levels of PCT (P=0.0001) and CRP (P=0.007), which means that the concentration of these two inflammatory biomarkers increased with an increase in the score of CURB-65 criteria. Moreover, there was a statistically significant association between the serum level of PCT and the outcomes of the disease (P<0.001). Conclusion: According to the results, the serum level of PCT or CRP is a strong prognostic factor for evaluating severity of CAP and is a suitable factor for the CURB-65 criteria in the decision making of whether a patient with CAP in the ICU should be admitted.
پژوهشگران فریبا کرامت (نفر اول)، حمیدرضا قاسمی بصیر (نفر دوم)، الهام عبدلی (نفر سوم)، ارغوان شفیعی اقدم (نفر چهارم)، جلال پورالعجل (نفر پنجم)