مشخصات پژوهش

صفحه نخست /Does zoledronate therapy make ...
عنوان
Does zoledronate therapy make mandibular bone susceptible to fracture? A radiographical and biomechanical study in rats
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
Zoledronate; Bisphosphonate; Mandible; Bone; Fracture
چکیده
Introduction: The aim of this study was to evaluate the effect of zoledronate therapy on susceptibility of mandibular bone to fracture in rats. Methods: Fifty rats were randomly allocated to two groups of 25 animals. The rats in group Z received monthly intravenous infusion of 0.06 mg/kg zoledronate for 6 months. The rats in the group C were injected with an equal volume of saline in the same manner. A month after the last zoledronate/saline administration, all 50 rats were euthanized. Using a cone beam computed tomography, the cortical thickness of inferior border of mandible and the mandibular bone mineral density were calculated, and using a three-point bending test, the pick load failure and the ultimate stress of mandibular bone were determined. Results: The mean mandibular inferior cortical bone thickness and the mean bone mineral density were significantly larger in zoledronate-treated rats (0.30 ± 0.02 mm and 1045.00 ± 185.79, respectively) compared to control rats (0.21 ± 0.01 mm and 878.66 ± 166.53, respectively). The pick load and the ultimate stress were lower in the zoledronate-treated hemimandibles (84.61 ± 33.62 N and 1.76 ± 0.72 MPa, respectively) compared to the control hemimandibles (98.36 ± 16.5 9 N and 2.03 ± 0.44 MPa, respectively). Conclusion: Zoledronate therapy was associated with an increased risk of mandibular fracture in rats.
پژوهشگران محمد زندی (نفر اول)، عباس شکری مرنی (نفر دوم)، سیده مریم موسوی (نفر سوم)، ساناز رجایی (نفر چهارم)، ناصر محمدقلی مزرجی (نفر پنجم)