مشخصات پژوهش

صفحه نخست /Extremely Low Frequency ...
عنوان
Extremely Low Frequency Electromagnetic Fields Decrease Serum Levels of Interleukin-17, Transforming Growth Factor-b and Downregulate Foxp3 Expression in the Spleen
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
interleukin-17, transforming growth factor-b, extremely low frequency of electromagnetic fields, retinoid-related orphan receptor gT, forkhead box P3, spleen, thymus
چکیده
he study aimed to determine effect of extremely low frequency (50 Hz) electromagnetic fields (ELF-EMFs) exposure on serum levels of interleukin-17 (IL-17) and transforming growth factor-b (TGF-b) as signature cytokines of Th17 and regulatory T (Treg) cells, respectively. Retinoid-related orphan receptor gT and transcription factor forkhead box P3 (Foxp3) expression levels as lineage defining of Th17 and Treg cells were also assessed in the spleen and thymus. Eighty male rats were separated into 4 exposed groups (1, 100, 500, and 2,000 mT magnetic flux intensities) and a control. All rats were immunized by human serum albumin after 1 month of the exposure and the experiment was continued in the same manner for 1 month more. The results demonstrated that the weight of thymuses was significantly declined at intensity of 2,000 mT. At the preimmunization phase, the serum levels of IL-17 and TGF-b were significantly decreased at intensities of 1 and 100 mT. The expression of Foxp3 was also downregulated at intensities of 1 and 100 mT. In conclusion, low intensities of ELF-EMF may reduce the serum levels of IL-17 and TGF-b and downregulate the expression of Foxp3 in spleen
پژوهشگران لیلا مهدوی نژاد (نفر اول)، مهدی بهزاد (نفر دوم)، محمد مهدی افتخاریان (نفر سوم)، زهره زارعی قانع (نفر چهارم)، ایرج صالحی (نفر پنجم)، مهرداد حاجیلوئی (نفر ششم به بعد)، هانیه محکی (نفر ششم به بعد)، علیرضا زمانی (نفر ششم به بعد)