مشخصات پژوهش

صفحه نخست /Association of IL-17 gene ...
عنوان
Association of IL-17 gene polymorphisms and susceptibility to brucellosis in Hamadan, western Iran.
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
IL-17; Iran; brucellosis; polymorphism
چکیده
Interleukin-17 is one of the most important inflammatory cytokines that stimulate immunity responses in human regarding to brucellosis, which as regulator reduces releasing of IFN-γ and will increase resistance to brucellosis. Gene polymorphisms affect the level of cytokine production in regulatory regions of cytokine encoding genes and play a fundamental role of infectious diseases. The aim of this study was to determine association of IL-17 gene polymorphisms and susceptibility to brucellosis. In this case-control study, 86 patients with brucellosis and 86 healthy persons in Hamadan, west of Iran, from Sept 2014 to Sept 2016, were included. The IL-17 genetic variants at positions rs4711998 A/G, rs8193036 C/T, rs3819024 A/G, rs2275913 A/G, rs3819025 A/G, rs8193038 A/G, rs3804513 A/T, rs1974226 A/G, rs3748067 A/G were analyzed by restriction fragment length polymorphism-polymerase chain reaction. Determination of serum IL-17 levels were carried out by a sandwich enzyme-linked immunosorbent assay. The GG genotypes at positions rs4711998 and rs3748067 were significantly in brucellosis patients compared to the controls (P<0.05). The AA genotype at positions rs4711998, rs2275913, rs3748067 and GG genotype at positions rs19744226 were significantly more frequent in controls than in the patients groups. These results suggest that the AA genotype at positions rs3748067, rs3819025, rs4711998 and GG genotype at positions rs3819024 may be consider as a protective factor for brucellosis, while the GG genotype at positions rs3748067, rs3819025, rs4711998 and AA genotype at positions rs3819024 might be a risk factor against the disease. No significant relationships were found between serum IL-17 levels and genotypes of the SNPs. This article is protected by copyright. All rights reserved
پژوهشگران فریبا کرامت (نفر اول)، سیما کاظمی (نفر دوم)، مسعود سعیدی جم (نفر سوم)، علیرضا زمانی (نفر چهارم)، حامد فرهادی کهن (نفر پنجم)، مژگان ممانی (نفر ششم به بعد)، پیمان عینی (نفر ششم به بعد)، عباس مقیم بیگی(تسویه حساب) (نفر ششم به بعد)، محمد یوسف علیخانی (نفر ششم به بعد)