مشخصات پژوهش

صفحه نخست /Drug Interactions Among ...
عنوان
Drug Interactions Among Hospitalized Patients in Intensive Care Units and Infectious Ward, Hamadan, Iran
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
Drug-drug interaction, Infectious diseases, Major interaction, Minor interaction
چکیده
Abstract Background:Drug interactions (DIs) are one of the problems caused by irrational drug use and includes the effects of drug, food, or anything that changes the pharmacokinetics or pharmacodynamics of a given drug. In this regard, DI is one of the causes of morbidity and mortality in patients. However, this problem is usually predictable and hence is required to be properly managed. The aim of the present study was to assess DIs in the patients hospitalized in the intensive care units and infectious ward of Sina hospital, Hamadan, Iran. Methods:This cross-sectional study was conducted on the medical records of 500 patients hospitalized in ICUs and infectious ward of Sina hospital in Hamadan from March 2014 to February 2015. The inclusion criterion was the presence of at least one DI in the patients hospitalized in the intensive care units (ICUs) and infectious ward of the hospital for at least 24 hours. The potential DIs were classified based on the type and severity. Medical and demographic characteristics of the patients, including age, sex, duration of hospitalization, inpatient ward, and treatment results (death or advances in treatment) were collected using a checklist. Data were analyzed using SPSS software version 16.0. Results:A total of 514 DIs were identified from which 5.05% were major and 41.82% were moderate interactions. The mean of DI per patient was 2.81 in the range of 1 and 23. The frequency of antibiotic/ antibiotic and antibiotic/other drugs interactions were 7.97% and 28.98%, respectively. The average length of stay in hospital was 12.07 days, and 26.22% and 25.13% of the studied patients were hospitalized in general and infectious ICUs, respectively. The mean of DIs per patient was significantly higher in infectious ICU rather than other studied wards. Conclusions:To sum up, although the percentage of major DIs were low, the prevalence of total DIs was high in the studied patients. Based on the results of this study, it seems that physici
پژوهشگران سارا عطایی (نفر اول)، محمد جباری (نفر دوم)، مریم مهرپویا (نفر سوم)، عباس طاهر (نفر چهارم)، جلال پورالعجل (نفر پنجم)، فریبا کرامت (نفر ششم به بعد)