مشخصات پژوهش

صفحه نخست /Hepatoprotective effects of ...
عنوان
Hepatoprotective effects of Pentoxifylline a phosphodiesterase-5 against acrolein- induced mitochondrial dysfunction in rat
نوع پژوهش مقاله ارائه شده (پوستر یا سخنرانی)
کلیدواژه‌ها
Pentoxifillin, Liver mitochondria, Oxidative stress, Rat, Acrolein
چکیده
Abstract Acrolein (ACR) is α, β unsaturated aldehyde that exists extensively in the environment and (thermally processed) foods. It can also be generated through endogenous metabolism. The aim of this study was to investigate the possible protective role of Pentoxifylline (PTX) is a non-selective phosphodiesterase (PDE) inhibitor on toxicity of ACR. In this study, oxidative damage were measured by markers of plasma and liver mitochondrial, such as, glutathione peroxidase (GPx), superoxide dismutase (SOD), lipid peroxidation (LPO) and total glutathione (GSH) in rats. Effective doses of ACR (2mg/kg/day) and PTX (50mg/kg/day) and vitamin E (15mg/kg/day) were administered alone or in combination for 14 days by intraperitoneal injection. At the end of the experiment, the liver mitochondria and plasma of the animals were separated. In the blood plasma, the LPO, SOD, and GPx were higher in the ACR group as compared with controls. PTX ameliorated LPO, SOD and GPx in blood of ACR-induced changes. Co-administration of PTX with ACR improved LPO and GSH in plasma and LPO in liver mitochondria. In conclusion, intracellular cAMP-elevating agents like PTX, may be considered beneficial for the protection or recovery of ACR-induced toxic damage in liver mitochondria and blood.
پژوهشگران اکرم رنجبر (نفر دوم)