مشخصات پژوهش

صفحه نخست /Propofol attenuates ...
عنوان
Propofol attenuates mitochondrial dysfunction- induced by CCL4 toxicity in rat liver mitochondria
نوع پژوهش مقاله ارائه شده (پوستر یا سخنرانی)
کلیدواژه‌ها
Propofol, Liver mitochondria, Oxidative stress, Rat, CCL4
چکیده
Antioxidant effects of Propofol (2, 6-diisopropylphenol) were evaluated against CCl4-induced oxidative stress in liver of rat. 30 male rats were equally divided in to 6 groups (05 rats each). Group I (control), while Group II was given CCl4 (3 ml /kg/day). Animals of Groups III received only Propofol (10 mg/kg/day, IP). Group IV was given Propofol+ CCl4. Group V was administered vitamin E (alpha-tocopherol acetate 15 mg/kg/day) .Animals of Group VII received alpha-tocopherol acetate + CCl4 once daily for two weeks. After treatment, blood and liver mitochondria were isolated. The activity of enzymatic scavengers such as glutathione peroxidase (GPx), superoxide dismutase (SOD), total glutathione (GSH) and lipid peroxidation (TBARS) concentration were measured. Oxidative stress induced with CCl4 in liver mitochondria was evident by a significant increase in enzymatic activities of GPx, SOD, and TBARS and reduce of GSH and availability of mitochondria. Propofol and vitamin E restored CCL4-induced changes in GSH, GPx, SOD and TBARS in blood and liver mitochondria. CCL4 decreased viability of mitochondria that was recovered by Propofol and vitamin E. It is concluded that oxidative damage is the mechanism of toxicity of CCL4 in the mitochondria that can be recovered by Propofol comparable to vitamin
پژوهشگران اکرم رنجبر (نفر اول)