مشخصات پژوهش

صفحه نخست /Comparison of body total ...
عنوان
Comparison of body total oxidative biomarkers in patients acute propofol exposure with ketamine
نوع پژوهش مقاله ارائه شده (پوستر یا سخنرانی)
کلیدواژه‌ها
Propofol, Oxidative stress, Blood, Ketamine
چکیده
Propofol (2, 6-diisopropylphenol) is a widely used intravenous sedative-hypnotic agent for both induction/maintenance of anesthesia and sedation of critically ill patients. The present study aimed to evaluate the effect of propofol and ketamine on the plasma oxidant-antioxidant profile in humans undergoing surgery at doses used to induce anesthesia. The plasma oxidative stress biomarkers such as total antioxidant capacity (TAC), lipid peroxidation (LPO), total thiol molecules (TTM) and antioxidant enzymes activity such as glutathione peroxidase (GPx), superoxidedismutase (SOD) and catalase (CAT) was studied in blood samples obtained from 40 patients with propofol, compared 40 patients with ketamine in the age range of 11–50 years. The results showed that ketamine group significantly higher blood LPO level, GPx and SOD activity in comparison to propofol group and concomitant lower blood TAC and TTM concentration in comparison to propofol group. In conclusion, our findings showed that propofol has antioxidant effects in human. Further studies need to be conducted to demonstrate the exact mechanism of oxidative stress due to anesthesia in surgery patients.
پژوهشگران اکرم رنجبر (نفر دوم)