مشخصات پژوهش

صفحه نخست /Differentiation of the ...
عنوان
Differentiation of the definitive endoderm from Wharton’s Jelly Mesenchymal Stem Cells (WJMSC)
نوع پژوهش مقاله چاپ شده
کلیدواژه‌ها
activin A, definitive endoderm, differentiation, Wharton’s jelly mesenchymal stem cells.
چکیده
Wharton’s jelly mesenchymal stem cells (WJMSCs) are multipotent cells derived from human um bilical cord that are viewed as promising candidate source of mesenchymal stem cells for rege - ne rative medicine. Apart from their accessibility, other advantages of WJMSCs include painless and non-invasive procedures to donor, immunomodulatory properties and faster self-renewal. In this study, we focused on differentiating WJMSCs into the definitive endoderm lineage as the first step in differentiation into endoderm derivatives, such as insulin-producing cells. The effect of various treatments on definitive endoderm differentiation was evaluated using real-time PCR to detect expression of four marker genes (i.e. Sox17, FoxA2, Cxcr4 and Cer). Here, we show that a low concentration of activin A in combination with Wnt3a promote differentiation of WJMSCs toward definitive endoderm. These findings may be of value
پژوهشگران قاسم سلگی (نفر پنجم)